Part1. What is Gymnema Extract Benefits?
Gymnema is a traditional Indian herb that has been used for more than 2,000 years. The ancient Indian Ayurveda Medicine (Ayurveda Medicine) records that chewing the leaves of this plant can destroy the sweetness of sugar. The sugar is like gravel in the mouth, but it melts slowly and does not feel its sweetness, so it is called " Sugar Busters".
Part2. Pharmacological function
Gymnema syringae has the effects of expelling wind and cooling blood, reducing swelling and relieving pain, strengthening stomach and diuresis. For anemofrigid-damp arthralgia, diabetes, vasculitis, etc. In recent years, scholars at home and abroad have found that it has the effects of lowering blood sugar, anti-caries and inhibiting sweetness response. It can also suppress the desire to eat sweets, inhibit the body's absorption of sugar, lower blood sugar, help repair damaged cells in the pancreas, and improve insulin secretion.
1. Hypoglycemic effect
The extract of Gymnema sylvestris has a mild effect on normal blood sugar, but when it is combined with glucose or sucrose, it can significantly inhibit the increase of blood sugar level and significantly reduce the secretion of plasma insulin.
2. Lowering blood fat and anti-atherosclerosis
Gymnema leaf extract can reduce serum triglyceride, total cholesterol, very low-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol levels in hyperlipidemic rats, and restore the low-density lipoprotein levels of hyperlipidemic rats. Protein-cholesterol and anti-atherosclerotic index.
3. Suppresses the sweetness response
Gymnema may inhibit the sweet response by blocking the sweet receptors on the surface of taste cells. Gymnemic acid is the main component of sweetness inhibitory effect. The presence of phthalein group plays an important role in the inhibition of sweetness response, which can cause taste loss. The rate is 77%. Peptide gurmarin can significantly inhibit the sweetness of lactose, maltose, saccharin, etc., and the inhibition rate is 40%-50%.
4. Anti-caries effect
Dental caries is caused by Streptococcus bacteria in the mouth that convert glucose into water-insoluble glucans, which stick to the enamel on the tooth surface. Gymnemic acid can significantly inhibit the activity of glucosyltransferase, block the synthesis of extracellular water-insoluble glucan of Streptococcus mutans, inhibit the formation of dental plaque, and make cariogenic bacteria lose their cariogenic environment, thereby achieving the effect of preventing caries.
5. Slimming effect
Gymnemic acid (GA) has the effect of losing weight because GA can not only reduce the desire for sweets, but also reduce the body's absorption of sugar. GChemicalbookA weakens the desire for sweets by reducing the sweetness of food without making it completely sweet, and the effect can last for 1-2 hours. Inhibiting the absorption of sugar is to control the absorption of sugar molecules in the intestine during digestion, which can effectively reduce the metabolism of sugar, thereby changing the absorption of sugar, thereby achieving the effect of changing blood sugar levels.
6. Anti-tumor and anti-inflammatory effects
The primary feature of tumors is malignant proliferation and an imbalance between cell proliferation and apoptosis. Anti-proliferation and pro-apoptosis are effective strategies for the treatment of tumors. Gymnemagenol in Gymnema can inhibit HepG2 cells (human liver cancer cells) in vitro, and Gymnema extract has significant activity against breast and lung cancer epithelial cells.
7. The role of anti-oxidation and radiation protection
Studies have found that the mechanism of Gymnema Gymnema's antioxidant effect is to exert its antioxidant effect by inhibiting DPPH free radicals and scavenging superoxide and hydrogen peroxide groups. The effective antioxidant components of Gymnema may be related to compounds such as flavonoids, phenols, saponins and triterpenes in Gymnema.
8. Antibacterial and antiviral effects
The inhibitory effect of Gymnema extract on bacteria, fungi and other microorganisms was studied, and it was found that different concentrations of natural saponins and purified saponins had obvious antibacterial effects.
9. Immunomodulatory effect
The water extract of Gymnema sylvestris has activity on human neutrophils and has a good immune regulation effect.
10. Other pharmacological effects
The crude extract of Gymnema can effectively kill the larvae of mosquitoes that can transmit malaria and filariasis, and is a natural insecticide, and has no toxic effect on the environment.
